Lactoferrin: a general review.
نویسندگان
چکیده
Lactoferrin is a 703-amino acid glycoprotein originally isolated from milk. Plasma lactoferrin is predominantly neutrophil derived but indications are that it may also be produced by other cells. Lactoferrin in body fluids is found in the iron-free form, the monoferric form and in the diferric form. Three isoforms of lactoferrin have been isolated, ie two with RNase activity (lactoferrin-beta and lactoferrin-gamma) and one without RNase activity (lactoferrin-alpha). Receptors for lactoferrin can be found on intestinal tissue, monocytes/macrophages, neutrophils, lymphocytes, platelets, and on certain bacteria. A wide spectrum of functions are ascribed to lactoferrin. These range from a role in the control of iron availability to immune modulation. More research is necessary however to obtain clarity with regard to the exact mechanism of action of lactoferrin.
منابع مشابه
Multifunctional iron bound lactoferrin and nanomedicinal approaches to enhance its bioactive functions.
Lactoferrin (Lf), an iron-binding protein from the transferrin family has been reported to have numerous functions. Even though Lf was first isolated from milk, it is also found in most exocrine secretions and in the secondary granules of neutrophils. Antimicrobial and anti-inflammatory activity reports on lactoferrin identified its significance in host defense against infection and extreme inf...
متن کاملLactoferrin: a review
This review discusses the biological properties of the glycoprotein lactoferrin. Lactoferrin has been identified in secretions from exocrine glands and in specific granules of neutrophils. After degranulation, neutrophils become the main source of lactoferrin in blood plasma. Lactoferrin possesses various biological functions, including roles in iron metabolism, cell proliferation and different...
متن کاملPROTECTIVE EFFECTS OF LACTOFERRIN AGAINST DORORUBICIN TOXICITY ON MAIN GONAD OF RAT
Background & Aims: Doxorubicin has been widely used to treat solid tumors and blood malignancies, but its toxicity has limited its application. The aim of the present study was to investigate the protective effects of lactoferrin against doxorubicin toxicity on the main gonad of rats. Materials & Methods: 24 Adult male Wistar rats were divided into four groups. Control group received physiolog...
متن کاملReview study on lactoferrin: A multifunctional protein
Lactoferrin is a glycoprotein of 703 amino acids originally isolated from milk. Lactoferrin exists in body fluids and can be found in the form of free iron, monoferric and diferic form. Scientist also found lactoferrin in the secretions of mammal’s pancreas, and in secondary neutrophil granules. Lactoferrin has wide range of functions which may range from binding of Lactoferrin with iron, in co...
متن کامل[Lactoferrin - a glycoprotein of great therapeutic potentials].
Lactoferrin is an iron-binding glycoprotein, which is present in most biological fluids with particularly high levels in colostrum and in mammalian milk. Bovine lactoferrin is more than 70% homologous with human lactoferrin. Most of the clinical trials have used bovine lactoferrin for supplementation. This review summarizes the recent advances in explaining the mechanisms, which are responsible...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Haematologica
دوره 80 3 شماره
صفحات -
تاریخ انتشار 1995